Canertinib

Product Name: Canertinib
CAS No.: 267243-28-7
Chemical Name: Canertinib
Synonyms: CS-152;PD-183805;Canetinib;Canertinib base;quinazolin-6-yl);CI-1033; PD-183805;CI-1033(Canertinib);Canertinib (CI-1033);Canertinib USP/EP/BP;-7-(3-morpholinopropoxy)
CBNumber: CB01458390
Molecular Formula: C24H25ClFN5O3
Formula Weight: 485.94
MOL File: 267243-28-7.mol

More

Less

Canertinib Property

Melting point:: 188-190°
Boiling point:: 691.0±55.0 °C(Predicted)
Density: 1.355±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥10.1 mg/mL in EtOH; ≥12.15 mg/mL in DMSO with gentle warming
form: Yellow powder.
pka: 12.09±0.43(Predicted)
CAS DataBase Reference: 267243-28-7

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: C175600
Product name: Canertinib
Packaging: 10mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-0121
Product name: Canertinib
Purity: 98.02%
Packaging: 100mg
Price: $137
Updated: 2021/12/16

AK Scientific

Product number: Y0252
Product name: Canertinib
Packaging: 25mg
Price: $170
Updated: 2021/12/16

ApexBio Technology

Product number: A1845
Product name: Canertinib(CI-1033)
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: A1845
Product name: Canertinib(CI-1033)
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

More

Less

Canertinib Chemical Properties,Usage,Production

Uses

CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.

Uses

Antineoplastic; irreversible pan-erbB tyrosine kinase inhibitor used to treat cancer.

Uses

Canertinib is a kind of irreversible pan-erbB tyrosine kinase inhibitor used to treat cancer.

Definition

ChEBI: A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.

Biological Activity

canertinib (also known as ci-1033), a 3-chloro, 4-fluoro, 4-anilinoquinazoline, is an orally available, potent and irreversible pan-erbb tyrosine kinase inhibitor that inhibits egfr, her2 and her4 in vitro with the half maximal inhibition concentration ic50 of 0.8 nm, 19 nm and 7 nm respectively [1].canertinib irreversibly binds into the atp pocket within the tk domain of all erbb family members, where the acrylamide side-chain at position c6 of canertinib is brought into close proximity with cysteines of erbb members, followed by the rapid formation of a covalent bond, which permanently inactivates the catalytically active erb1, erb2 and erb4 family members and effectively inhibits erbb3-dependent signaling [2].

References

[1] michelle arkin, mark m. moasser. her2 directed small molecule antagonists. curr opin investig drugs. author manuscript; available in pmc 2011 february 1. published in final edited form as: curr opin investig drugs. 2008 december; 9(12): 1264–1276.
[2] calvo e, tolcher aw, hammond la, patnaik a, de bono js, eiseman ia, olson sc, lenehan pf, mccreery h, lorusso p, rowinsky ek. administration of ci-1033, an irreversible pan-erbb tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase i pharmacokinetic and food effect study. clin cancer res. 2004 nov 1;10(21):7112-20.

Canertinib Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Canertinib Suppliers

China 134 India 2 United Kingdom 2 United States 28 Global 166

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

ALB Technology Limited

Tel: 702-983-3769
Fax: 702-983-3769
Email: sales@albtechnology.com
Country: United States
ProdList: 2993
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

More

Less

View Lastest Price from Canertinib manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Canertinib 267243-28-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

Dideu Industries Group Limited

Product: CANERTINIB
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: canertinib 267243-28-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

267243-28-7, CanertinibRelated Search:

AG 1478 HYDROCHLORIDE DAPH AG 18 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH AG 825 TYRPHOSTIN A25 PD 173074 Bortezomib Selumetinib GDC-0068 Erlotinib hydrochloride Olaparib AG 213 CIVENTICHEM CV-409 Canertinib dihydrochloride Canertinib

CS-152

CI-1033; PD-183805; CI1033; CI 1033; PD183805; PD 183805

CI-1033 (Canertinib, PD-183805)

CI-1033(Canertinib)

PD-183805

CI-1033; PD-183805

Canertinib base

Canetinib

Canertinib (CI-1033)

N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide

N-[4-(3-chloro-4-fluoro-anilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide

N-[4-(3-chloro-4-fluoroanilino)-7-(3-Morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-en

2-PropenaMide,N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-(4-Morpholinyl)propoxy]-6-quinazolinyl]-

N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide

Canertinib N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide

N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide Canertinib (CI-1033)

Canertinib--CI-1033, PD-183805

-7-(3-morpholinopropoxy)

N-(4-((3-Chloro-4-fluorophenyl)

quinazolin-6-yl)

Canertinib USP/EP/BP

ErbB-1,inhibit,Inhibitor,PD 183805,PD183805,Epidermal growth factor receptor,CI 1033,HER1,Orthopoxvirus,Canertinib,EGFR,CI1033

267243-28-7

C23H23ClFN5O3

Inhibitors